US RDA
90 to 120 mcg daily (combined K1 and K2)
Effective dose
90 to 180 mcg daily MK-7 form
Upper limit
No established upper limit for K2. Very safe.
Timing
With largest fat-containing meal
With food
Yes, requires dietary fat
Bioavailability
MK-7 (long-chain) > MK-4 (short-chain) for sustained blood levels
Best forms to buy
MK-7 90 to 180 mcg
Long-lasting, best for daily use
MK-4
Shorter duration, higher dose needed
Combined MK-4 and MK-7
Full spectrum
Signs of deficiency
- · Vascular calcification
- · Bone weakness
- · Poor calcium utilization
Drug interactions
- · Blood thinners (particularly warfarin)
Toxicity
None known.