US RDA
No official RDA. AI (adequate intake) 1.1 to 1.6 g ALA daily
Effective dose
1,000 to 2,000 mg combined EPA + DHA daily
Upper limit
3,000 mg daily EPA + DHA is generally recognized as safe
Timing
With largest meal
With food
Yes, requires dietary fat
Bioavailability
Triglyceride form and phospholipid (krill) are more bioavailable than ethyl ester
Best forms to buy
Triglyceride form
Best bioavailability
Krill oil
Phospholipid form, more absorbable per mg
Algal oil
Vegan DHA source
Ethyl ester
Least absorbable, avoid if possible
Signs of deficiency
- · Dry skin
- · Poor concentration
- · Joint stiffness
- · Depression
Drug interactions
- · Blood thinners (increased bleeding risk at high doses)
- · Blood pressure medications
Toxicity
Rare. Fishy burps, digestive upset, bleeding risk at very high doses.