US RDA
N/A (herbal supplement)
Effective dose
300 to 600 mg daily of KSM-66 or Sensoril standardized extract
Upper limit
Doses up to 1,200 mg daily used in trials without significant adverse effects
Timing
Morning or split AM/PM. Evening if for sleep support.
With food
Optional
Bioavailability
Standardized extracts (KSM-66, Sensoril) most reliable
Best forms to buy
KSM-66 extract
Most researched, whole-root water extract
Sensoril
High withanolide content, more calming
Raw powder
Less standardized, harder to dose
Signs of deficiency
- · Not applicable
Drug interactions
- · Sedatives
- · Thyroid medications (may increase T4)
- · Immunosuppressants
Toxicity
Well tolerated. Rare digestive upset. Avoid in pregnancy, hyperthyroidism, and autoimmune conditions.